DAZL A386G gene mutation and male infertility: A genetic association analysis of Asian population

Genetic susceptibility has a prominent role in infertility. This study was proposed the association of Deleted in Azoospermia-Like (DAZL) A386G gene transition with male infertility in an Iranian population which followed by a meta-analysis in Asian population. In the case-control study we collected blood samples from 100 idiopathic infertile and 100 healthy fertile men. After DNA extraction, DAZL A386G genotyping was performed by PCR-RFLP method. In meta-analysis, we found eligible papers by searching in standard databases. Case-control study indicated that there is no signifi cant association between DAZL A386G and male infertility in study population. However in metaanalysis, we found a signifi cant association between DAZL A386G and male infertility in G vs. A (OR= 8.33, 95% CI= 3.56-19.46, P < 0.001), AG vs. AA (OR= 7.60, 95% CI= 3.24-17.82, P < 0.001), and AG+GG vs. AA (OR= 8.13, 95% CI= 3.47-19.07, P < 0.001) genetic models within Asian population. Therefore, we concluded that DAZL A386G can be considered as a possible risk factor for susceptibility to male infertility within Asian population. However, further studies with larger sample sizes are required to obtain more accurate data.